Supramolecular sensor for cancer-associated nitrosamines.

نویسندگان

  • Tsuyoshi Minami
  • Nina A Esipenko
  • Ben Zhang
  • Maria E Kozelkova
  • Lyle Isaacs
  • Ryuhei Nishiyabu
  • Yuji Kubo
  • Pavel Anzenbacher
چکیده

A supramolecular assay based on two fluorescent cucurbit[n]uril probes enables the recognition and quantification of nitrosamines, including cancer-associated nitrosamines, compounds that are difficult to recognize. The cross-reactive sensor leverages weak interactions and competition among the probe, metal, and guest, yielding high information density in the signal output (variance) and enabling the recognition of structurally similar guests.

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عنوان ژورنال:
  • Journal of the American Chemical Society

دوره 134 49  شماره 

صفحات  -

تاریخ انتشار 2012